Caspase Recruitment Domain Family Member 11 (CARD11) Antibody
357.5€ (100 µg)
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Name
Caspase Recruitment Domain Family Member 11 (CARD11) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx037167
Tested Applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the CARD11 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Caspase Recruitment Domain Family Member 11 (CARD11) Immunogen: Recombinant fragment corresponding to 23-178 AA of human CARD11. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 133 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | CARD-containing MAGUK protein 1,CARMA1,BENTA, BIMP3, CARMA1, IMD11, IMD11A, PPBL |
| Background | Antibody anti-CARD11 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CARD11, also known as CARMA1 (Caspase Recruitment Domain-Containing Membrane-Associated Protein 1), is a critical protein in the immune system, particularly in T-cell receptor (TCR) and B-cell receptor (BCR) signaling. It acts as an adaptor protein, linking upstream receptor activation to downstream signaling pathways, including the NF-κB pathway. NF-κB activation plays an essential role in the immune response, cell survival, and inflammation. CARD11 is crucial in immune cell activation, differentiation, and the production of pro-inflammatory cytokines. Mutations or dysregulation of CARD11 can result in immune system disorders, including lymphomas, and are implicated in autoimmune diseases such as systemic lupus erythematosus (SLE). Studies of CARD11's role in immune cell signaling have made it a potential therapeutic target for regulating immune responses and treating inflammatory or autoimmune diseases.
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