CTDSP2 antibody
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Description
Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain(CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | CTD(carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 (CTDSP2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 31 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | O14595 |
| Gene ID | 10106 |
| Alias | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2,Nuclear LIM interactor-interacting factor 2 (NLI-interacting factor 2),Protein OS-4,Small C-terminal domain phosphatase 2,Small CTD phosphatase 2 (SCP2),CTDSP2,NIF2,OS4,SCP2 |
| Background | Antibody anti-CTDSP2 |
| Status | RUO |
| Note | Mol. Weight 31 kDa |
Descripción
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