DOCK8 antibody
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Name
DOCK8 antibody
Category
Primary Antibodies
Provider
FineTest
Reference
FNab02498
Tested Applications
ELISA, WB, IHC
Description
Potential guanine nucleotide exchange factor(GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP(By similarity).
Documentos del producto
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | dedicator of cytokinesis 8 (DOCK8) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 230-239 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8NF50 |
| Gene ID | 81704 |
| Alias | HEL-205,HIES2,MRD2,ZIR8 |
| Background | Antibody anti-DOCK8 |
| Status | RUO |
| Note | Mol. Weight 230-239 kDa |
Background
DOCK8 is a GEF primarily activating Rac1 and Cdc42, critical for actin cytoskeleton regulation, immune cell migration, and synapse formation. It is essential for lymphocyte survival, intercellular adhesion, and immune synapse organization. DOCK8 deficiency causes DOCK8 immunodeficiency syndrome, characterized by recurrent infections, allergies, and autoimmunity. It interacts with proteins like WASP and ELMO to promote immune cell migration and T-cell activation. DOCK8 is highly expressed in hematopoietic cells, particularly T and B cells. Dysregulation impairs lymphocyte trafficking and survival, contributing to immune dysfunction. Studies in knockout models show defects in T-cell proliferation, migration, and immune surveillance.
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