Docking Protein 8 (DOCK8) Antibody
637€ (100 µl)
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Name
Docking Protein 8 (DOCK8) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx112013
Tested Applications
ELISA, WB
Description
Dedicator Of Cytokinesis 8 Antibody is a Rabbit Polyclonal antibody against Dedicator Of Cytokinesis 8.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Docking Protein 8 (DOCK8) Immunogen: Human DOCK8. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8NF50 |
| Gene ID | 81704 |
| NCBI Accession | NP_001177387.1, NM_001190458.1, NP_001180465.1, NM_001193536.1, NP_982272.2, NM_203447.3 |
| OMIM | 243700 |
| Alias | HEL-205,HIES2,MRD2,ZIR8 |
| Background | Antibody anti-DOCK8 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
DOCK8 is a GEF primarily activating Rac1 and Cdc42, critical for actin cytoskeleton regulation, immune cell migration, and synapse formation. It is essential for lymphocyte survival, intercellular adhesion, and immune synapse organization. DOCK8 deficiency causes DOCK8 immunodeficiency syndrome, characterized by recurrent infections, allergies, and autoimmunity. It interacts with proteins like WASP and ELMO to promote immune cell migration and T-cell activation. DOCK8 is highly expressed in hematopoietic cells, particularly T and B cells. Dysregulation impairs lymphocyte trafficking and survival, contributing to immune dysfunction. Studies in knockout models show defects in T-cell proliferation, migration, and immune surveillance.
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