EXD1 antibody
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Description
RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity(By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease(By similarity).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | exonuclease 3'-5' domain containing 1 (EXD1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:200-1:1000; IHC: 1:50-1:500; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 36 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8NHP7 |
| Gene ID | 161829 |
| Alias | piRNA biogenesis protein EXD1,Exonuclease 3'-5' domain-containing protein 1,Exonuclease 3'-5' domain-like-containing protein 1,Inactive exonuclease EXD1,EXD1,EXDL1 |
| Background | Antibody anti-EXD1 |
| Status | RUO |
| Note | Mol. Weight 36 kDa |
Descripción
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