HLA-DMB antibody
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Description
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide(CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | major histocompatibility complex, class II, DM beta (HLA-DMB) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 29 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P28068 |
| Gene ID | 3109 |
| Alias | HLA class II histocompatibility antigen, DM beta chain,MHC class II antigen DMB,Really interesting new gene 7 protein,HLA-DMB,DMB,RING7 |
| Background | Antibody anti-HLA-DMB |
| Status | RUO |
| Note | Mol. Weight 29 kDa |
Descripción
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HLA-DMB antibody
Plays a critical role in catalyzing the release of class II-associated invariant chain peptide(CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO.
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HLA Class II Histocompatibility Antigen, DM Beta Chain (HLA-DMB) Antibody
HLA-DMB Antibody is a Rabbit Polyclonal Antibody against HLA-DMB.
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HLA Class II Histocompatibility Antigen, DM Beta Chain (HLA-DMB) Antibody
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
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