HOMER2 antibody

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935106861
info@markelab.com
name
HOMER2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab03964
tested applications
ELISA, WB
Description
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses(PubMed:9808459). Required for normal hearing(PubMed:25816005).
Documents del producto
Product specifications
Category | Primary Antibodies |
Immunogen Target | homer homolog 2(Drosophila) (HOMER2) |
Host | Rabbit |
Reactivity | Human |
Recommended Dilution | WB: 1:500-1:2000 |
Clonality | polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Observed MW | 39 kDa |
Purity | ≥95% as determined by SDS-PAGE |
Purification | Immunogen affinity purified |
Size 1 | 100µg |
Form | liquid |
Tested Applications | ELISA, WB |
Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
UniProt ID | Q9NSB8 |
Gene ID | 9455 |
Alias | Homer protein homolog 2 (Homer-2),Cupidin,HOMER2 |
Background | Antibody anti-HOMER2 |
Status | RUO |
Note | Mol. Weight 39 kDa |
Descripción
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Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses(PubMed:9808459). Required for normal hearing(PubMed:25816005).
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