IWS1 antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Transcription factor which plays a key role in defining the composition of the RNA polymerase II(RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain(CTD) of the RNAPII subunit RPB1(POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors(ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes(such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | IWS1 homolog (IWS1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IP: 1:200-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 116-120 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IP |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q96ST2 |
| Gene ID | 55677 |
| Alias | Protein IWS1 homolog,IWS1-like protein,IWS1,IWS1L |
| Background | Antibody anti-IWS1 |
| Status | RUO |
| Note | Mol. Weight 116-120 kDa |
Descripción
Related Products
IWS1 antibody
Transcription factor which plays a key role in defining the composition of the RNA polymerase II(RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain(CTD) of the RNAPII subunit RPB1(POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors(ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes(such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.
Ver Producto
IWS1, SUPT6H Interacting Protein (IWS1) Antibody
IWS1 Antibody is a Rabbit Polyclonal antibody against IWS1.
Ver Producto
IWS1, SUPT6H Interacting Protein (IWS1) Antibody
IWS1 Antibody is a Rabbit Polyclonal Antibody against IWS1.
Ver Producto