KCNA5 antibody
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Description
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel(PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation(PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation(PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation(PubMed:11524461).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | potassium voltage-gated channel, shaker-related subfamily, member 5 (KCNA5) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 67 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P22460 |
| Gene ID | 3741 |
| Alias | Potassium voltage-gated channel subfamily A member 5,HPCN1,Voltage-gated potassium channel HK2,Voltage-gated potassium channel subunit Kv1.5,KCNA5 |
| Background | Antibody anti-KCNA5 |
| Status | RUO |
| Note | Mol. Weight 67 kDa |
Descripción
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