NCOA3 antibody
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Description
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids(GR and ER), retinoids(RARs and RXRs), thyroid hormone(TRs), vitamin D3(VDR) and prostanoids(PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | nuclear receptor coactivator 3 (NCOA3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 160kd |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IF, IHC, FC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9Y6Q9 |
| Gene ID | 8202 |
| Alias | Nuclear receptor coactivator 3 (NCoA-3),ACTR,Amplified in breast cancer 1 protein (AIB-1),CBP-interacting protein (pCIP),Class E basic helix-loop-helix protein 42 (bHLHe42),Receptor-associated coactivator 3 (RAC-3),Steroid receptor coactivator protein 3 (SRC-3),Thyroid hormone receptor activator molecule 1 (TRAM-1),NCOA3,AIB1,BHLHE42,RAC3,TRAM1 |
| Background | Antibody anti-NCOA3 |
| Status | RUO |
| Note | Mol. Weight 160 kDa |
Descripción
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NCOA3 antibody
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids(GR and ER), retinoids(RARs and RXRs), thyroid hormone(TRs), vitamin D3(VDR) and prostanoids(PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.
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