PARP3 antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Involved in the base excision repair(BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | poly(ADP-ribose) polymerase family, member 3 (PARP3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 60-62 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9Y6F1 |
| Gene ID | 10039 |
| Alias | Protein mono-ADP-ribosyltransferase PARP3,ADP-ribosyltransferase diphtheria toxin-like 3 (ARTD3),DNA ADP-ribosyltransferase PARP3,IRT1,NAD(+) ADP-ribosyltransferase 3 (ADPRT-3),Poly [ADP-ribose] polymerase 3 (PARP-3, hPARP-3),Poly[ADP-ribose] synthase 3 (pADPRT-3),PARP3,ADPRT3,ADPRTL3 |
| Background | Antibody anti-PARP3 |
| Status | RUO |
| Note | Mol. Weight 60-62 kDa |
Descripción
Related Products
PARP3 antibody
Involved in the base excision repair(BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
Ver Producto
Poly ADP Ribose Polymerase 3 (PARP3) Antibody
PARP3 Antibody is a Rabbit Polyclonal antibody against PARP3. The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.
Ver Producto
Poly ADP Ribose Polymerase 3 (PARP3) Antibody
Rabbit polyclonal antibody against PARP3 protein. Immunogen region is N-terminal.
Ver Producto