POLG2 antibody
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Description
This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | polymerase (DNA directed), gamma 2, accessory subunit (POLG2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 55 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, IHC, WB, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q9UHN1 |
| Gene ID | 11232 |
| Alias | DNA polymerase subunit gamma-2, mitochondrial,DNA polymerase gamma accessory 55 kDa subunit (p55),Mitochondrial DNA polymerase accessory subunit,MtPolB,PolG-beta,POLG2,MTPOLB |
| Background | Antibody anti-POLG2 |
| Status | RUO |
| Note | Mol. Weight 55 kDa |
Descripción
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POLG2 antibody
This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.
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