RFFL antibody
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Description
E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ring finger and FYVE-like domain containing 1 (RFFL) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1:500-1:2000 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 37-41 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | Q8WZ73 |
| Gene ID | 117584 |
| Alias | E3 ubiquitin-protein ligase rififylin,Caspase regulator CARP2,Caspases-8 and -10-associated RING finger protein 2 (CARP-2),FYVE-RING finger protein Sakura (Fring),RING finger and FYVE-like domain-containing protein 1,RING finger protein 189,RING finger protein 34-like,RING-type E3 ubiquitin transferase rififylin,RFFL,RNF189,RNF34L |
| Background | Antibody anti-RFFL |
| Status | RUO |
| Note | Mol. Weight 37-41 kDa |
Descripción
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RFFL antibody
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