SEPTIN2 antibody

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935106861
info@markelab.com
name
SEPTIN2 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab07722
tested applications
ELISA, WB, IHC, IF

Description

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex(also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
septin 2 (SEPTIN2)
Host
Mouse
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:2000-1:20000; IHC: 1:50-1:2000; IF: 1:20-1:200
Clonality
monoclonal
Conjugation
Unconjugated
Isotype
IgG1
Clone ID
8H4
Observed MW
43 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Protein A+G purification
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC, IF
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
Q15019
Gene ID
4735
Alias
Septin-2,Neural precursor cell expressed developmentally down-regulated protein 5 (NEDD-5),SEPTIN2,DIFF6,KIAA0158,NEDD5,SEPT2
Background
Antibody anti-SEPTIN2
Status
RUO
Note
Mol. Weight 43 kDa

Descripción

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