Atypical Chemokine Receptor 4 (ACKR4) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
Atypical Chemokine Receptor 4 (ACKR4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015221
tested applications
ELISA, WB, IF/ICC
Description
Rabbit polyclonal antibody against CCRL1 protein. Immunogen region is N-terminal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Atypical Chemokine Receptor 4 (ACKR4) Immunogen: The antiserum was produced against synthesized peptide derived from N-terminal of human CCRL1. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, IF/ICC: 1/100 - 1/500, ELISA: 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NPB9 |
| Alias | ACKR4,PPR1,CCBP2,CCR10,CCR11,CCRL1,VSHK1,CCR-11,CKR-11,CCX CKR,CCX-CKR,CC-CKR-11 |
| Background | Antibody anti-ACKR4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
ACKR4 is a non-signaling chemokine receptor that acts as a scavenger receptor for homeostatic chemokines, including CCL19, CCL21, and CXCL13, which are critical for lymphoid tissue organization and immune cell trafficking. By internalizing and degrading its ligands, ACKR4 modulates chemokine gradients and prevents excessive immune cell recruitment, contributing to immune homeostasis. It is predominantly expressed in lymphatic endothelial cells, thymic epithelial cells, and certain stromal cells, where it regulates the migration and positioning of T cells, dendritic cells, and other immune cells. ACKR4 plays a key role in T-cell development, particularly in guiding thymocytes during positive and negative selection in the thymus. Dysregulation of ACKR4 has been implicated in autoimmune diseases, inflammatory conditions, and tumor metastasis, where altered chemokine gradients can lead to immune cell mislocalization and dysregulated immune responses. Its regulatory role in chemokine biology underscores ACKR4’s importance in maintaining immune balance and preventing pathological inflammation.
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