Caspase Recruitment Domain-Containing Protein 14 (CARD14) Antibody
260€ (50 µl)
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Name
Caspase Recruitment Domain-Containing Protein 14 (CARD14) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx211747
Tested Applications
ELISA, WB, IHC
Description
CARD14 Antibody is a Rabbit Polyclonal against CARD14.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Caspase Recruitment Domain-Containing Protein 14 (CARD14) Immunogen: Fusion protein of human CARD14. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, WB: 1/200 - 1/1000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BXL6 |
| Gene ID | 79092 |
| OMIM | 173200 |
| Alias | CARD14,BIMP2, CARMA2, PRP, PSORS2, PSS1,CARD-containing MAGUK protein 2 |
| Background | Antibody anti-CARD14 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CARD14, also known as CARMA2 (Caspase Recruitment Domain-Containing Membrane-Associated Protein 2), is a protein that plays an important role in immune cell signaling, especially in the activation of NF-κB and other inflammatory pathways. It acts as an adaptor protein in the NF-κB signaling cascade, which is crucial for the immune response to pathogens. CARD14 is involved in various immune system functions, including the regulation of cytokine production and the activation of immune cells in response to infection. Recent studies have shown that CARD14 mutations are associated with psoriasis, an autoimmune skin disorder, suggesting that its regulation of immune responses is vital for maintaining immune system balance. Inappropriate activation or suppression of CARD14 may lead to the development of chronic inflammatory diseases, making it a potential target for therapeutic interventions in conditions such as psoriasis and other immune-related diseases.
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