Cyclin-Dependent Kinase 1 (CDK1) Antibody
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Description
The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis.Cdc2 exists as a complex with both cyclin A and cyclin B.The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition.Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161.However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14.Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase.The isoform CDC2deltaT is found in breast cancer tissues.Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Cyclin-Dependent Kinase 1 (CDK1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC, FCM |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P06493 |
| Gene ID | 983 |
| OMIM | 116940 |
| Background | Antibody anti-CDC2 |
| Status | RUO |
| Note | Concentration: Not determined. - |
Descripción
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Cyclin-Dependent Kinase 1 (CDK1) Antibody
The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2 delta T is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.
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Cyclin-Dependent Kinase 1 (CDK1) Antibody
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Cyclin-Dependent Kinase 1 (CDK1) Antibody
The cell division control protein cdc2, also known as cyclin-dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S-phase and mitosis.Cdc2 exists as a complex with both cyclin A and cyclin B.The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition.Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161.However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14.Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase.The isoform CDC2deltaT is found in breast cancer tissues.Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.
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