DCC-Interacting Protein 13-Beta (APPL2) Antibody
292.5€ (80 µl)
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Name
DCC-Interacting Protein 13-Beta (APPL2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx029544
Tested Applications
ELISA, WB
Description
Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: DCC-Interacting Protein 13-Beta (APPL2) Immunogen: KLH-conjugated synthetic peptide between 124-152 amino acids from the N-terminal region of human APPL2. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 74.5 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8NEU8 |
| Alias | DIP13B,Dip13-beta,Adapter protein containing PH domain, PTB domain and leucine zipper motif 2 |
| Background | Antibody anti-APPL2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
APPL2 (Phosphotyrosine Interacting with PH Domain and Leucine Zipper 2) is another member of the APPL protein family, similar to APPL1. Like APPL1, APPL2 also contains a pleckstrin homology (PH) domain and a leucine zipper, enabling it to interact with phosphotyrosine-containing proteins. APPL2 is involved in a wide range of cellular processes including endocytosis, signal transduction, and the regulation of vesicular trafficking. It is particularly important in regulating the function of the insulin receptor and in modulating signaling pathways that control cell growth, survival, and metabolism. APPL2 is known to affect cellular responses to growth factors and contributes to the regulation of neuronal function and plasticity. Its role in intracellular signaling makes it a relevant protein in understanding diseases like diabetes and neurodegenerative conditions.
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