Docking Protein 7 (DOCK7) Antibody
377€ (100 µg)
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Name
Docking Protein 7 (DOCK7) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx232497
Tested Applications
ELISA, WB, IP
Description
DOCK7 Antibody is a Rabbit Polyclonal against DOCK7.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Docking Protein 7 (DOCK7) Immunogen: dedicator of cytokinesis 7 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/200 - 1/1000, IP: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 240 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IP |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96N67 |
| Gene ID | 85440 |
| OMIM | 615730 |
| Alias | DEE23, EIEE23, ZIR2,KIAA1771 |
| Background | Antibody anti-DOCK7 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
DOCK7 is a GEF for Rac1 and Cdc42, playing a key role in axon formation, neuronal polarization, and Schwann cell myelination. It regulates actin cytoskeleton dynamics and microtubule stabilization in neurons. DOCK7 interacts with the WAVE complex to promote Rac1-mediated actin remodeling, essential for neuronal growth and cortical development. It also regulates cell cycle progression in neural progenitors and is involved in epithelial-to-mesenchymal transition (EMT) in cancer. DOCK7 dysregulation is linked to neurological disorders and tumor progression. Mouse models with DOCK7 loss exhibit defects in neural development, including axonal growth and Schwann cell function.
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