D4 Dopamine Receptor (DRD4) Antibody
52€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
D4 Dopamine Receptor (DRD4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015231
tested applications
ELISA, WB, IF/ICC
Description
D4 Dopamine Receptor (DRD4) Antibody is a Rabbit polyclonal against D4 Dopamine Receptor (DRD4).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: D4 Dopamine Receptor (DRD4) Immunogen: The antiserum was produced against a synthetic peptide derived from the internal region of Human DRD4. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | ELISA: 1/40000, WB: 1/500 - 1/3000, IF/ICC: 1/100 - 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C for up to 1 year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21917 |
| Alias | DRD4,d(2C) dopamine receptor,dopamine receptor 4,D4R |
| Background | Antibody anti-DRD4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
DRD4 is a Gi/o-coupled G protein-coupled receptor of the D2-like dopamine receptor family, primarily expressed in brain regions associated with cognition, emotion, and reward, such as the prefrontal cortex, amygdala, and hippocampus. DRD4 plays a significant role in modulating attention, impulse control, and executive function, and its dysfunction has been linked to attention-deficit hyperactivity disorder (ADHD), schizophrenia, and other neuropsychiatric disorders. Notably, DRD4 is highly polymorphic, with variations in its gene (e.g., the 7-repeat allele) associated with ADHD susceptibility, novelty-seeking behavior, and addiction. DRD4 signaling inhibits adenylate cyclase activity, leading to reduced cyclic AMP (cAMP) levels, and influences downstream pathways like MAPK and protein kinase C (PKC), regulating neuronal excitability and plasticity. In addiction, DRD4 contributes to reward sensitivity and reinforcement learning, making it a target for substance abuse treatment. DRD4 is also expressed in peripheral tissues, where it modulates cardiovascular function and immune responses. Its polymorphic nature and role in attention and behavior make DRD4 a key target for ADHD therapeutics and neuropsychiatric research.
Related Products
Rat DRD4 (Dopamine Receptor D4) ELISA Kit
Ver Producto
DRD4 antibody
Ver Producto
D4 Dopamine Receptor (DRD4) Antibody
D4 Dopamine Receptor (DRD4) Antibody is a Rabbit polyclonal against D4 Dopamine Receptor (DRD4).
Ver Producto