E3 Ubiquitin-Protein Ligase CBL-B (CBLB) Antibody
637€ (100 µl)
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Name
E3 Ubiquitin-Protein Ligase CBL-B (CBLB) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx111410
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
E3 Ubiquitin-Protein Ligase CBL-B (CBLB) Antibody is a Rabbit Polyclonal antibody against E3 Ubiquitin-Protein Ligase CBL-B (CBLB).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: E3 Ubiquitin-Protein Ligase CBL-B (CBLB) Immunogen: Human CBLB. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13191 |
| Gene ID | 868 |
| NCBI Accession | NP_001308717.1, NM_001321788.1 |
| OMIM | 604491 |
| Alias | CBL-B,CBLB,Cbl-b, RNF56, ADMIO3, Nbla00127 |
| Background | Antibody anti-CBLB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CBLB, another member of the CBL family, shares a similar function to CBL in ubiquitinating target proteins, but it has its unique set of substrates and regulatory roles. CBLB primarily regulates immune cell signaling, particularly in T and B cells, by modulating receptor signaling pathways involved in immune responses. It is involved in the regulation of T-cell receptor (TCR) signaling, and its activity helps in controlling the activation threshold of immune cells. Similar to CBL, CBLB can influence the stability of receptors and other signaling molecules by mediating their degradation. Altered expression or mutations in CBLB can affect immune responses, and it has been linked to autoimmune diseases and immune deficiencies.
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