F-Box Protein 9 (FBXO9) Antibody
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Description
F-Box Protein 9 Antibody is a Rabbit Polyclonal antibody against F-Box Protein 9.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | F-Box Protein 9 (FBXO9) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UK97 |
| Gene ID | 26268 |
| NCBI Accession | NP_036479.1, NM_012347.4 |
| OMIM | 609091 |
| Background | Antibody anti-FBXO9 |
| Status | RUO |
Descripción
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FBXO9 antibody
Substrate recognition component of a SCF(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.
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F-Box Protein 9 (FBXO9) Antibody
F-Box Protein 9 Antibody is a Rabbit Polyclonal antibody against F-Box Protein 9.
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