Fibroblast Growth Factor Receptor Substrate 3 (FRS3) Antibody
357.5€ (100 µg)
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Name
Fibroblast Growth Factor Receptor Substrate 3 (FRS3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx146107
Tested Applications
ELISA, WB, IHC
Description
FRS3 Antibody is a Rabbit Polyclonal against FRS3.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Fibroblast Growth Factor Receptor Substrate 3 (FRS3) Immunogen: Recombinant fragment corresponding to 54-231 AA of human FRS3. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 54 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_006653.4 |
| Alias | FRS2-beta,FRS2B,FRS2beta,SNT-2,SNT2,FGFR substrate 3,FGFR-signaling adaptor SNT2 |
| Background | Antibody anti-FRS3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Fibroblast growth factor receptor substrate 3 (FRS3) is another adaptor protein involved in FGFR signaling pathways. Like FRS2, FRS3 becomes tyrosine-phosphorylated upon FGFR activation and serves as a scaffold for the assembly of signaling complexes. FRS3 interacts with various signaling proteins, including Grb2 and Sos, to activate the Ras/MAPK pathway, promoting cellular proliferation and differentiation. Although FRS3 shares functional similarities with FRS2, it is known for its distinct tissue distribution and specific engagement with particular FGFR isoforms. These unique interactions suggest that FRS3 may play specialized roles in certain biological contexts. FRS3's involvement in FGFR signaling also links it to developmental processes and pathological conditions such as cancer. Understanding FRS3's unique contributions to FGFR signaling can provide insights into its potential as a therapeutic target in diseases involving aberrant FGFR activity.
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