Glycophorin C (GYPC) Antibody
195€ (20 µl)
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935106861
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name
Glycophorin C (GYPC) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx001144
tested applications
ELISA, WB
Description
GYPC Antibody is a Rabbit Polyclonal antibody against GYPC. Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Glycophorin C (GYPC) Immunogen: Recombinant protein corresponding to GYPC. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 14 kDa Observed MW: 34 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P04921 |
| Gene ID | 2995 |
| NCBI Accession | NP_002092.1 |
| Alias | Gerbich blood group,GE,GPC,GPD,GYPD,CD236,PAS-2,CD236R,Glycoconnectin,Glycophorin-D,Glycoprotein beta, |
| Background | Antibody anti-GYPC |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Glycophorin C (GYPC) is a membrane glycoprotein found primarily on the surface of red blood cells (RBCs). It is a member of the glycophorin family, which includes Glycophorin A (GYPA) and Glycophorin B (GYPB). GYPC plays a crucial role in maintaining the structural integrity of the RBC membrane and contributes to the MNS blood group system. The protein is encoded by the GYPC gene located on chromosome 2. Along with its homologs GYPA and GYPB, GYPC is involved in defining RBC membrane characteristics, including cell shape, flexibility, and interactions with the cytoskeleton. GYPC, specifically, is known to carry the M and N antigens of the MNS blood group system, which are significant in transfusion medicine. In addition to its structural function in the RBC membrane, GYPC plays a role in the function of the erythrocyte by interacting with various signaling molecules and maintaining the membrane's elasticity and resistance to mechanical stresses. Its functional importance in RBCs, as well as its potential relevance in certain disease states, makes it a significant protein in both clinical and biological research.
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GYPC Antibody is a Rabbit Polyclonal antibody against GYPC. Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].
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