Human FRS2 (Fibroblast Growth Factor Receptor SubstRate 2) ELISA Kit
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Name
Human FRS2 (Fibroblast Growth Factor Receptor SubstRate 2) ELISA Kit
Category
ELISA Kits
Provider
FineTest
Reference
EH3084
Tested Applications
ELISA
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 15.625-1000pg/ml |
| Sensitivity | 9.375pg/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | Q8WU20 |
| Alias | FRS2A, FRS2alpha, SNT, SNT-1, SNT1, FRS1A,FGFR substrate 2,FGFR-signaling adaptor SNT |
| Background | Elisa kits for FRS2 |
| Status | RUO |
Background
Fibroblast growth factor receptor substrate 2 (FRS2) is an intracellular adaptor protein that plays a pivotal role in the signaling pathways of fibroblast growth factor receptors (FGFRs). Upon FGFR activation, FRS2 becomes tyrosine-phosphorylated and acts as a docking platform for various signaling molecules. It primarily facilitates the recruitment of Grb2 and Sos, leading to the activation of the Ras/MAPK pathway, which is essential for cell proliferation, differentiation, and survival. FRS2 also interacts with Shp2, linking FGFR activation to the phosphatidylinositol 3-kinase (PI3K) pathway, which regulates cell survival and metabolic processes. FRS2 is highly involved in developmental processes and is often implicated in diseases such as cancer, where FGFR signaling is dysregulated. Its role as a signaling hub makes it a critical component in cellular communication and a potential target for therapeutic interventions in FGFR-related disorders.
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