Human Killer Cell Immunoglobulin Like Receptor 2DS4 (KIR2DS4) Protein

Este producto es parte de KIR2DS4 - Killer cell immunoglobulin-like receptor 2DS4
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208€ (10 µg)

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935106861
info@markelab.com
name
Human Killer Cell Immunoglobulin Like Receptor 2DS4 (KIR2DS4) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067651
tested applications
WB, SDS-PAGE

Description

Human Killer Cell Immunoglobulin Like Receptor 2DS4 (KIR2DS4) is a recombinant Human protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Killer Cell Immunoglobulin Like Receptor 2DS4 (KIR2DS4)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Gln22-Ser302
Tag: N-terminal His tag
Origin
Human
Conjugation
Unconjugated
Observed MW
Calculated MW: 32.3 kDa  Observed MW (SDS-PAGE): 32 kDa
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
P43632
Alias
CD158 antigen-like family member I,KKA3,KIR1D,Natural killer-associated transcript 8,NKAT8,CD158I,KIR412,NKAT-8,KIR-2DS4,P58 natural killer cell receptor clones CL-39/CL-17
Background
Protein KIR2DS4
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Descripción

Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4) is part of the Killer-cell Immunoglobulin-like Receptor (KIR) family, which plays a central role in the immune system, specifically in regulating natural killer (NK) cells and certain T-cell functions. KIR2DS4 is one of the activating receptors in the KIR family and is particularly involved in identifying cells that may be infected, stressed, or tumorigenic. KIR receptors, including KIR2DS4, contribute to the immune system's adaptability through interactions with human leukocyte antigen (HLA) molecules, typically class I. However, unlike many KIR receptors that mediate inhibitory signals, KIR2DS4 is an activating receptor. It provides stimulatory signals that help NK cells become cytotoxic toward specific target cells. KIR genes, including KIR2DS4, are highly polymorphic, with substantial genetic variation between individuals, contributing to variations in immune response. KIR genes are clustered on chromosome 19, and their expression varies across different populations, impacting immune response diversity. This variation has implications for disease susceptibility, transplantation compatibility, and response to certain therapies.

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