Human Leucine Rich Repeat Containing Protein 10 (LRRC10) ELISA Kit
715€ (96 tests)
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name
Human Leucine Rich Repeat Containing Protein 10 (LRRC10) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx388314
tested applications
ELISA
Description
Human Leucine Rich Repeat Containing Protein 10 (LRRC10) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human LRRC10 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Leucine Rich Repeat Containing Protein 10 (LRRC10) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.094 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q5BKY1 |
| Gene ID | 376132 |
| OMIM | 610846 |
| Alias | LRRC10 |
| Background | Elisa Kits for: LRRC10 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
LRRC10 is a heart-specific protein indispensable for proper cardiac development and contractile function. It acts as a cofactor in sarcomeric assembly, ensuring the structural organization of cardiac myofibrils, particularly at the Z-disc. LRRC10's deficiency has been linked to dilated cardiomyopathy (DCM), a condition characterized by ventricular enlargement and systolic dysfunction leading to heart failure. It also plays a role in mechanotransduction, influencing excitation-contraction coupling and calcium handling in cardiomyocytes. Studies involving LRRC10 knockout models reveal embryonic lethality or severe cardiomyopathy phenotypes, underscoring its importance in cardiogenesis. In adult models, LRRC10 dysfunction exacerbates cardiac remodeling under stress conditions, suggesting a protective role in cardiac adaptation. Furthermore, it may regulate sarcomeric protein phosphorylation, influencing contractility. Research is underway to explore its utility as a diagnostic marker or therapeutic target for heart failure, particularly in genetic forms of cardiomyopathy, as mutations in LRRC10 have been found in familial DCM cases, highlighting its clinical significance.
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Human Leucine Rich Repeat Containing Protein 10 (LRRC10) ELISA Kit
Human Leucine Rich Repeat Containing Protein 10 (LRRC10) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human LRRC10 concentrations in tissue homogenates, cell lysates and other biological fluids.
Ver Producto