Human Sialic Acid Binding Ig Like Lectin 14 (SIGLEC14) Protein

221€ (10 µg)
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name
Human Sialic Acid Binding Ig Like Lectin 14 (SIGLEC14) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx069066
tested applications
WB, SDS-PAGE
Description
Human Sialic Acid Binding Ig Like Lectin 14 (SIGLEC14) is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Sialic Acid Binding Ig Like Lectin 14 (SIGLEC14) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Gln24-Leu137 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 19.1 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q08ET2 |
| Alias | Siglec-14 |
| Background | Protein SIGLEC14 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
SIGLEC14 is a member of the Siglec family expressed on myeloid cells, including monocytes and neutrophils. It is paired with SIGLEC5, with which it shares high sequence similarity, forming an activating counterpart to the inhibitory SIGLEC5. SIGLEC14 binds to sialic acid-containing glycans on pathogens and self-tissues, triggering pro-inflammatory responses. This protein has been implicated in innate immune activation, particularly in recognizing bacterial infections. SIGLEC14 also plays a role in the modulation of immune responses, balancing activation and tolerance. Genetic variations in SIGLEC14 can result in a fusion with SIGLEC5, altering its expression and immune function.
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