Human TNF Receptor Associated Factor 5 (TRAF5) Protein

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Description
Human TRAF5 (TRAF5) is a recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | TNF Receptor Associated Factor 5 (TRAF5) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Gln181-Arg437 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 33.8 kDa Observed MW (SDS-PAGE): 35 kDa |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00463 |
| Alias | TRAF-5,TRAF5, MGC:39780, RNF84, TNF receptor associated factor 5 |
| Background | Protein TRAF5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
TRAF5 is a signaling adaptor protein that mediates pathways downstream of TNF receptors (TNFR), CD40, and BAFF-R, activating NF-κB and JNK to regulate inflammation, immune cell activation, and survival. TRAF5 plays a critical role in adaptive immune responses, particularly in T and B cell activation, cytokine production, and lymphoid tissue development. It works redundantly with TRAF2 to promote canonical NF-κB activation, ensuring appropriate immune responses to inflammatory and survival signals. TRAF5 is widely expressed in immune cells and epithelial tissues, where it supports cellular signaling during infections and tissue repair. Dysregulation of TRAF5 contributes to autoimmune diseases and inflammatory conditions, where altered NF-κB signaling enhances cytokine production and immune cell proliferation. Knockout studies reveal defects in lymphocyte activation, impaired cytokine signaling, and altered immune responses, highlighting its importance in immune regulation and inflammatory signaling.
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