Importin Subunit Alpha-2 (KPNA2) Antibody
442€ (200 µl)
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name
Importin Subunit Alpha-2 (KPNA2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430366
tested applications
P-ELISA, WB, IHC, IF/ICC, FCM
Description
KPNA2 Antibody is a Goat Polyclonal antibody against KPNA2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Importin Subunit Alpha-2 (KPNA2) Immunogen: abx269466 - C-Terminus: C-QVQDGAPGTFNF |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC, IF/ICC, FCM |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 3838, 16647, 85245 |
| NCBI Accession | NP_002257.1 |
| Alias | KPNA2,IPOA1, QIP2, RCH1, SRP1alpha, Karyopherin alpha 2, SRP1-alpha, karyopherin subunit alpha 2, PTAC58 |
| Background | Antibody anti-KPNA2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
KPNA2, also known as importin-α2, is a key nuclear transport adaptor protein that binds cargo proteins containing classical nuclear localization signals (NLS). It works in conjunction with importin-β to translocate the cargo through the nuclear pore complex (NPC) into the nucleus. KPNA2 is ubiquitously expressed and is involved in processes like gene expression, DNA repair, and cell proliferation. It has been shown to play a significant role in cancer biology, where overexpression of KPNA2 is associated with tumor progression, metastasis, and poor prognosis in cancers such as breast, lung, and liver cancers. KPNA2 also facilitates the nuclear import of viral proteins, making it a target in viral pathogenesis. Knockout studies indicate that KPNA2 is essential for cell viability and differentiation, particularly during embryogenesis and immune cell development.
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