Importin Subunit Alpha-7 (KPNA6) Antibody
195€ (20 µl)
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Name
Importin Subunit Alpha-7 (KPNA6) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx006643
Tested Applications
ELISA, WB
Description
KPNA6 Antibody is a Rabbit Polyclonal Antibody against KPNA6.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Importin Subunit Alpha-7 (KPNA6) Immunogen: Recombinant protein corresponding to KPNA6. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/1000 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 60 kDa Observed MW: 60 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O60684 |
| Gene ID | 23633 |
| NCBI Accession | NP_036448.1 |
| Alias | KPNA6,IPOA7,Importin subunit alpha-7 |
| Background | Antibody anti-KPNA6 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
KPNA6, also called importin-α7, is a nuclear transport adaptor protein that interacts with importin-β to mediate the nuclear import of cargo proteins containing classical nuclear localization signals (NLS). It plays key roles in cellular processes such as transcriptional regulation, cell cycle control, and DNA repair. KPNA6 is highly expressed in embryonic tissues, germ cells, and immune cells, where it supports cellular differentiation and developmental processes. It has been implicated in nuclear import during viral infections, where it facilitates the entry of viral proteins into the nucleus. Dysregulation of KPNA6 is associated with developmental defects, cancer progression, and immune dysfunction. Knockout studies reveal its critical function in early embryogenesis, nuclear transport efficiency, and maintaining proper gene expression regulation during cellular growth and differentiation.
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