Integrin alpha-5 (ITGA5) Antibody
286€ (0.1 mg)
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935106861
info@markelab.com
name
Integrin alpha-5 (ITGA5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx347354
tested applications
FCM, IHC
Description
Integrin alpha-5 (ITGA5) Antibody is a Mouse Monoclonal antibody for Integrin alpha-5 (ITGA5).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Integrin alpha-5 (ITGA5) Immunogen: U937 cells. |
| Host | Mouse |
| Reactivity | Human, Monkey |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | FCM: 1-4 μg/ml. Optimal dilutions/concentrations should be determined by the end user.. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2b |
| Clone ID | Y741 |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | FCM, IHC |
| Buffer | PBS, pH 7.4, containing 15 mM sodium azide. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P08648 |
| Gene ID | 3678 |
| Alias | FNRA,CD49e,VLA-5,VLA5A,Integrin alpha-5,Integrin alpha-5,Fibronectin receptor subunit alpha,Integrin alpha-F |
| Background | Antibody anti-ITGA5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
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Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site(site 2) which is distinct from the classical ligand-binding site(site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1(PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1(FBN1) and mediates R-G-D-dependent cell adhesion to FBN1(PubMed:12807887, PubMed:17158881).
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