Karyopherin Alpha 3 (KPNA3) Antibody
357.5€ (100 µg)
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name
Karyopherin Alpha 3 (KPNA3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx145912
tested applications
ELISA, WB, IHC
Description
KPNA3 Antibody is a Rabbit Polyclonal against KPNA3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Karyopherin Alpha 3 (KPNA3) Immunogen: Recombinant fragment corresponding to 28-208 AA of human KPNA3. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 58 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | BC035090 |
| Alias | QIP2,Importin alpha Q2,Importin subunit alpha-4,SRP1,SRP4,IPOA4,SPG88; Hsrp1,SRP1gamma |
| Background | Antibody anti-KPNA3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
KPNA3, or importin-α3, is another member of the importin-α family that mediates the nuclear import of cargo proteins with classical nuclear localization signals (NLS). It interacts with importin-β to form a complex that transports cargo proteins through the nuclear pore complex (NPC). KPNA3 is expressed in various tissues and is particularly important in regulating nuclear transport during cell signaling, differentiation, and immune responses. It has roles in viral infections, where it mediates the nuclear import of viral proteins such as influenza and HIV components, aiding viral replication. Dysregulation of KPNA3 is associated with neurological disorders and cancer, where it influences nuclear transport of transcription factors and oncogenes. Knockout and functional studies show its essential role in maintaining cellular homeostasis and regulating nuclear import efficiency during development and stress responses.
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