Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 1 (MAP3K7IP1) Antibody
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Description
MAP3K7IP1 Antibody is a Rabbit Polyclonal antibody against MAP3K7IP1. The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Mitogen Activated Protein Kinase Kinase Kinase 7 Interacting Protein 1 (MAP3K7IP1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15750 |
| Gene ID | 10454 |
| NCBI Accession | NP_006107.1 |
| Background | Antibody anti-MAP3K7IP1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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