Mouse Nucleoporin 133 kDa (NUP133) Protein
234€ (10 µg)
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name
Mouse Nucleoporin 133 kDa (NUP133) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx068356
tested applications
WB, SDS-PAGE
Description
Mouse Nucleoporin 133 kDa (NUP133) is a recombinant Mouse protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Nucleoporin 133kDa (NUP133) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Leu36-His240 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 25.7 kDa Observed MW (SDS-PAGE): 26 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8R0G9 |
| Alias | GAMOS8,NPHS18,Hnup133,nucleoporin 133kDa,Nuclear pore complex protein Nup133 |
| Background | Protein NUP133 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
Nucleoporin 133 (NUP133) is a nucleoporin involved in the nuclear pore complex, which regulates the selective transport of molecules between the nucleus and cytoplasm NUP133 is essential for the structural integrity of the nuclear pore and is involved in the formation of the central channel that facilitates the trafficking of RNA, proteins, and ribosomal subunits NUP133 plays a critical role in ensuring efficient gene expression by allowing the proper export of mRNA from the nucleus to the cytoplasm for translation Dysregulation of NUP133 has been associated with cellular processes such as the cell cycle, DNA repair, and immune responses It is particularly important for maintaining nuclear function during cell division and ensuring the proper functioning of mitosis NUP133 has also been implicated in cancer, where alterations in nucleocytoplasmic transport contribute to abnormal gene expression and tumor progression Its role in regulating cell cycle checkpoints and maintaining genomic stability makes NUP133 crucial for proper cell function and tissue homeostasis
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