Nischarin (NISCH) Antibody
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Description
NISCH Antibody is a Rabbit Polyclonal Antibody against NISCH.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Nischarin (NISCH) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y2I1 |
| Gene ID | 11188 |
| NCBI Accession | NP_009115.2 |
| Background | Antibody anti-NISCH |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
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NISCH antibody
Acts either as the functional imidazoline-1 receptor(I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla(RVLM) neurons that exhibited rilmenidine-evoked hypotension(By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons(By similarity). Acts as a modulator of Rac-regulated signal transduction pathways(By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity(By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation(By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation(By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells(By similarity). Inhibits lamellipodia formation, when overexpressed(By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.
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Nischarin (NISCH) Antibody
Nischarin Antibody is a Rabbit Polyclonal antibody against Nischarin.
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