Osteopontin (SPP1) Antibody
195€ (20 µl)
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935106861
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name
Osteopontin (SPP1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx001202
tested applications
ELISA, WB
Description
SPP1 Antibody is a Rabbit Polyclonal antibody against SPP1. Osteopontin (SPP1), also designated bone sialoprotein 1, urinary stone protein, spp-1, Eta-1, nephropontin and uropontin, is an extracellular matrix cell adhesion phosphoglycoprotein. SPP1 is deposited into unmineralized matrix prior to calcification leading to localization at various tissue interfaces including cement lines, lamina limitans and between collagen fibrils of fully matured hard tissues. While SPP1 is a major product of osteoblasts, it is also synthesized by brain and kidney cells. SPP1 isolated from or secreted by various tissues ranges in molecular weight due to posttranslational modifications. SPP1 functions as a substrate for transglutaminase and is involved in cell adhesion, chemoattraction and immunomodulation.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Osteopontin (SPP1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/1000 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10451 |
| Gene ID | 6696 |
| NCBI Accession | NP_001035147.1 |
| Background | Antibody anti-SPP1 |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
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SPP1 antibody
Osteopontin(OPN), also known as SPP1, is a secreted glycophosphoprotein that belongs to the small integrin-binding ligand N-linked glycoprotein(SIBLING) family. Originally isolated from bone, OPN has been found in kidney, vascular tissues, biological fluids, and various tumor tissues(PMID: 15138464; 16406521). OPN can interact with CD44 and integrins and regulate diverse biological processes. It has a multifaceted role in bone development and remodeling, and is also involved in the inflammatory and immune response, oncogenesis and cancer progression.
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