Pleckstrin Homology Domain-Containing Family A Member 6 (PLEKHA6) Antibody
292.5€ (80 µl)
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Name
Pleckstrin Homology Domain-Containing Family A Member 6 (PLEKHA6) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx029805
Tested Applications
ELISA, WB
Description
PEPP3 contains an N-terminal pleckstrin homology (PH) domain. It shares significant homology with PEPP1 and PEPP2 only in the PH domain.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Pleckstrin Homology Domain-Containing Family A Member 6 (PLEKHA6) Immunogen: KLH-conjugated synthetic peptide between 710-736 amino acids from the Central region of human PLEKHA6. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 0.34 mg/ml |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 117 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y2H5 |
| Alias | KIAA0969, PEPP3,PH domain-containing family A member 6,Phosphoinositol 3-phosphate-binding protein 3,PEPP-3 |
| Background | Antibody anti-PLEKHA6 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PLEKHA6 is a member of the pleckstrin homology (PH) domain-containing protein family that interacts with phosphoinositides, enabling its recruitment to plasma and endosomal membranes for the regulation of intracellular signaling and vesicle trafficking. It functions as a scaffold protein that coordinates the localization and activity of signaling molecules involved in cytoskeletal dynamics, endocytosis, and cellular adhesion. PLEKHA6 is expressed in epithelial, endothelial, and immune cells, where it regulates processes like cell migration, polarity, and tissue remodeling. Dysregulation of PLEKHA6 has been implicated in cancer metastasis and inflammatory disorders due to its role in actin reorganization and cell adhesion dynamics. Knockout studies demonstrate defects in membrane trafficking, impaired cellular adhesion, and reduced migration, highlighting its essential role in coordinating phosphoinositide-mediated signaling pathways, cytoskeletal organization, and cellular polarity.
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