Prostaglandin E Receptor 1 (PTGER1) Antibody
260€ (50 µl)
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935106861
info@markelab.com
name
Prostaglandin E Receptor 1 (PTGER1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx214377
tested applications
ELISA, WB
Description
PTGER1 Antibody is a Rabbit Polyclonal against PTGER1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Prostaglandin E Receptor 1 (PTGER1) Immunogen: Synthetic peptide of human PTGER1. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, WB: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P34995 |
| Gene ID | 5731 |
| Alias | PTGER1,EP1 prostanoid receptor,PGE receptor EP1 subtype,prostanoid EP1 receptor,prostaglandin E receptor 1 (subtype EP1) |
| Background | Antibody anti-PTGER1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
PTGER1, or EP1, is a G protein-coupled receptor activated by prostaglandin E2 (PGE2), a key mediator of inflammation, pain, and fever. PTGER1 couples to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium levels, and modulating downstream signaling pathways that regulate smooth muscle contraction, pain perception, and inflammation. PTGER1 is expressed in smooth muscle cells, neurons, and immune cells, where it plays a critical role in pain sensitization, gastric acid secretion, and vascular responses. Activation of PTGER1 enhances nociceptive signaling in peripheral sensory neurons, contributing to inflammatory pain and hyperalgesia. In the gastrointestinal system, PTGER1 regulates acid secretion and mucosal protection, while in the vasculature, it mediates vasoconstriction. Dysregulation of PTGER1 is associated with inflammatory diseases, pain disorders, and gastric ulcers. PTGER1 antagonists are being explored for treating inflammatory pain, arthritis, and gastric acid-related conditions by modulating PGE2-induced effects on inflammation and nociception.
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