Protein CutA (CUTA) Antibody
312€ (60 µl)
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935106861
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name
Protein CutA (CUTA) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx006908
tested applications
WB
Description
CUTA Antibody is a Rabbit Polyclonal Antibody against CUTA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Protein CutA (CUTA) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O60888 |
| Gene ID | 51596 |
| NCBI Accession | NP_001014840.1 |
| Alias | ACHAP,C6orf82 |
| Background | Antibody anti-CUTA |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
The cutA divalent cation tolerance homolog (CUTA) is a highly conserved protein that plays a role in cellular tolerance to divalent metal cations, such as copper, zinc, and nickel. It is ubiquitously expressed in various tissues and is localized in both the cytoplasm and mitochondria, where it is thought to regulate metal ion homeostasis and protect cells from metal-induced toxicity. CUTA is implicated in modulating mitochondrial function and redox balance by ensuring appropriate cation levels, which are essential for enzymatic activities and structural stability within the organelle. Dysregulation of CUTA expression or function has been associated with mitochondrial dysfunction and oxidative stress, which are linked to neurodegenerative diseases, including Alzheimer's disease. CUTA has also been suggested to have a role in copper homeostasis, as it may influence copper-binding proteins and prevent copper-induced oxidative damage. Although its precise mechanisms of action remain under investigation, CUTA's involvement in metal ion detoxification and mitochondrial health makes it a potential target for understanding and treating conditions associated with metal ion imbalance.
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