Protein Tyrosine Phosphatase, Receptor Type C Associated Protein (PTPRCAP) Antibody
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Description
The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Protein Tyrosine Phosphatase, Receptor Type C Associated Protein (PTPRCAP) Immunogen: KLH-conjugated synthetic peptide between 90-118 amino acids from the Central region of human PTPRCAP. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 21.2 kDa |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q14761 |
| Alias | LPAP,CD45-AP,PTPRCAP,CD45-associated protein,Lymphocyte phosphatase-associated phosphoprotein,PTPRC-associated protein,Protein tyrosine phosphatase receptor type C-associated protein |
| Background | Antibody anti-PTPRCAP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Protein Tyrosine Phosphatase Receptor Type C Associated Protein (PTPRCAP), also known as CD45-associated protein, is a regulatory component of the CD45 phosphatase complex. CD45 is a transmembrane protein tyrosine phosphatase expressed on all nucleated hematopoietic cells and is essential for T-cell receptor (TCR) and B-cell receptor (BCR) signaling. PTPRCAP modulates CD45 activity, influencing immune cell activation, proliferation, and differentiation. It contributes to the regulation of lymphocyte signaling thresholds, thereby impacting immune responses and tolerance. Alterations in PTPRCAP expression or function are implicated in immune-related disorders, including autoimmunity and immunodeficiency. The protein plays a role in maintaining immune homeostasis and is a subject of interest for therapeutic interventions targeting immune dysregulation. Further studies are needed to clarify its precise mechanisms and broader biological roles in immune signaling.
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