PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) Antibody
377€ (100 µg)
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Name
PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx233732
Tested Applications
ELISA, WB, IHC
Description
GULP1 Antibody is a Rabbit Polyclonal against GULP1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: PTB Domain Containing Engulfment Adapter Protein 1 (GULP1) Immunogen: GULP, engulfment adaptor PTB domain containing 1 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 45 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UBP9 |
| Gene ID | 51454 |
| OMIM | 608165 |
| Alias | GULP1,CED6,GULP,CED-6 |
| Background | Antibody anti-GULP1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
GULP1 is an adaptor protein containing a phosphotyrosine-binding (PTB) domain that mediates signal transduction in cell engulfment, phagocytosis, and apoptotic cell clearance. It interacts with transmembrane receptors like integrins and members of the engulfment pathway, including the CED-1 homologs. GULP1 facilitates actin cytoskeletal rearrangement by bridging receptors to downstream signaling proteins during phagosome formation. It is essential for apoptotic cell removal and has roles in cell migration and lipid homeostasis. GULP1 is expressed in macrophages, epithelial cells, and neurons, where it regulates tissue remodeling and cellular debris clearance. Dysregulation is linked to impaired phagocytosis, inflammatory diseases, and neurodegenerative disorders. Studies in knockout models highlight its role in maintaining immune homeostasis and preventing chronic inflammation.
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