Rab Proteins Geranylgeranyltransferase Component A 1 (CHM) Antibody
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Description
CHM Antibody is a Rabbit Polyclonal Antibody against CHM.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Rab Proteins Geranylgeranyltransferase Component A 1 (CHM) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P24386 |
| Gene ID | 1121 |
| NCBI Accession | NP_000381.1 |
| Background | Antibody anti-CHM |
| Status | RUO |
| Note | Concentration: > 0.2 mg/ml - |
Descripción
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CHM antibody
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Rab Proteins Geranylgeranyltransferase Component A 1 (CHM) Antibody
CHM Antibody is a Rabbit Polyclonal Antibody against CHM.
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Rab Proteins Geranylgeranyltransferase Component A 1 (CHM) Antibody
This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.
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