Rap Guanine Nucleotide Exchange Factor 3 (RAPGEF3) Antibody
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Description
RAPGEF3 Antibody is a Rabbit Polyclonal antibody against RAPGEF3. EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signaling in part through protein kinase A (PKA) (reviewed in 1). EPAC signaling plays a significant role in a number of cellular processes including migration and focal adhesion formation (2), exocytosis (3), insulin signaling (4), axon growth and guidance (5) and neurotransmitter release (6).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Rap Guanine Nucleotide Exchange Factor 3 (RAPGEF3) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95398 |
| Gene ID | 10411 |
| NCBI Accession | NP_001092002.1 |
| OMIM | 606057 |
| Background | Antibody anti-RAPGEF3 |
| Status | RUO |
| Note | Concentration: 0.35 mg/ml - |
Descripción
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RAPGEF3 antibody
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Rap Guanine Nucleotide Exchange Factor 3 (RAPGEF3) Antibody
RAPGEF3 Antibody is a Rabbit Polyclonal antibody against RAPGEF3. EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signaling in part through protein kinase A (PKA) (reviewed in 1). EPAC signaling plays a significant role in a number of cellular processes including migration and focal adhesion formation (2), exocytosis (3), insulin signaling (4), axon growth and guidance (5) and neurotransmitter release (6).
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Rap Guanine Nucleotide Exchange Factor 3 (RAPGEF3) Antibody
RAPGEF3 Antibody is a Rabbit Polyclonal antibody against RAPGEF3.
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