Rat Fibroblast Growth Factor Receptor Substrate 3 (FRS3) ELISA Kit

Este producto es parte de FRS - Fibroblast growth factor receptor substrate
Rat Fibroblast Growth Factor Receptor Substrate 3 (FRS3) ELISA Kit
715€ (96 tests)

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Name
Rat Fibroblast Growth Factor Receptor Substrate 3 (FRS3) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx256925
Tested Applications
ELISA

Description

Rat Fibroblast Growth Factor Receptor Substrate 3 (FRS3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Fibroblast Growth Factor Receptor Substrate 3 (FRS3) concentrations in tissue homogenates, cell lysates and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
ELISA Kits
Immunogen Target
Fibroblast Growth Factor Receptor Substrate 3 (FRS3)
Reactivity
Rat
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.156 ng/ml - 10 ng/ml
Sensitivity
0.1 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard Form: Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-7 working days.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
Q52RG8
Gene ID
316213
NCBI Accession
NP_001017382.1
Alias
FRS2-beta,FRS2B,FRS2beta,SNT-2,SNT2,FGFR substrate 3,FGFR-signaling adaptor SNT2
Background
Elisa Kits for: FRS3
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

Fibroblast growth factor receptor substrate 3 (FRS3) is another adaptor protein involved in FGFR signaling pathways. Like FRS2, FRS3 becomes tyrosine-phosphorylated upon FGFR activation and serves as a scaffold for the assembly of signaling complexes. FRS3 interacts with various signaling proteins, including Grb2 and Sos, to activate the Ras/MAPK pathway, promoting cellular proliferation and differentiation. Although FRS3 shares functional similarities with FRS2, it is known for its distinct tissue distribution and specific engagement with particular FGFR isoforms. These unique interactions suggest that FRS3 may play specialized roles in certain biological contexts. FRS3's involvement in FGFR signaling also links it to developmental processes and pathological conditions such as cancer. Understanding FRS3's unique contributions to FGFR signaling can provide insights into its potential as a therapeutic target in diseases involving aberrant FGFR activity.

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