Ribosomal RNA Processing 8, Methyltransferase, Homolog (Yeast) (RRP8) Antibody
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Description
RRP8 Antibody is a Rabbit Polyclonal against RRP8.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Ribosomal RNA Processing 8, Methyltransferase, Homolog (Yeast) (RRP8) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200, IF/ICC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O43159 |
| Gene ID | 23378 |
| OMIM | 615818 |
| Background | Antibody anti-RRP8 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
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RRP8 antibody
Essential component of the eNoSC(energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9'(H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
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Ribosomal RNA Processing 8, Methyltransferase, Homolog (Yeast) (RRP8) Antibody
RRP8 Antibody is a Rabbit Polyclonal against RRP8.
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Ribosomal RNA Processing 8, Methyltransferase, Homolog (Yeast) (RRP8) Antibody
RRP8 Antibody is a Rabbit Polyclonal against RRP8.
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