RIC8 Guanine Nucleotide Exchange Factor A (RIC8A) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G (i) alpha protein, possibly leading to release G (i) alpha-GTP and NuMA proteins from the NuMA-GPSM2-G (i) alpha-GDP complex (By similarity). Also acts as an activator for G (q) alpha (GNAQ) protein by enhancing the G (q) coupled receptor-mediated ERK activation.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | RIC8 Guanine Nucleotide Exchange Factor A (RIC8A) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NPQ8 |
| Background | Antibody anti-RIC8A |
| Status | RUO |
Descripción
Related Products
RIC8A antibody
Guanine nucleotide exchange factor(GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex(By similarity). Also acts as an activator for G(q)-alpha(GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
Ver ProductoRIC8A antibody
Guanine nucleotide exchange factor(GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex(By similarity). Also acts as an activator for G(q)-alpha(GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
Ver Producto
RIC8 Guanine Nucleotide Exchange Factor A (RIC8A) Antibody
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G (i) alpha protein, possibly leading to release G (i) alpha-GTP and NuMA proteins from the NuMA-GPSM2-G (i) alpha-GDP complex (By similarity). Also acts as an activator for G (q) alpha (GNAQ) protein by enhancing the G (q) coupled receptor-mediated ERK activation.
Ver Producto