Serine/Threonine-Protein Kinase LMTK1 (AATK) Antibody
273€ (100 µl)
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935106861
info@markelab.com
name
Serine/Threonine-Protein Kinase LMTK1 (AATK) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx103799
tested applications
IHC
Description
Polyclonal Antibody to Apoptosis Associated Tyrosine Kinase (AATK).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Serine/Threonine-Protein Kinase LMTK1 (AATK) Immunogen: AATK (Tyr137-Gln386) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB (Predicted): 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q80YE4 |
| Gene ID | 11302 |
| Alias | AATYK,AATYK1,LMR1,LMTK1,PPP1R77,P35bp,AATK |
| Background | Antibody anti-AATK |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
AATK (Apoptosis-Associated Tyrosine Kinase), also known as LMTK1 (Lemur Tyrosine Kinase 1), is a member of the serine/threonine-protein kinase family. PTKs (Protein Tyrosine Kinases) facilitate the transfer of the gamma-phosphoryl group from ATP to tyrosine (Tyr) residues. LMTK1, also known as Apoptosis-associated tyrosine kinase (AATK) or AATYK, is a cytoplasmic kinase with an extensive C-terminal region. The expression of LMTK1 is elevated during growth arrest and apoptosis in myeloid cells . LMTK1 is implicated in neural differentiation and serves as a regulator for the Na-K-2Cl cotransporter, a membrane protein involved in cell proliferation, survival, epithelial transport, and blood pressure control. The protein comprises a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. Studies on the mouse homologue suggest its potential role in inducing growth arrest and apoptosis in myeloid precursor cells. Additionally, it may play a part in promoting differentiation in neuronal cells . Recent reports also highlight its suppressive effect on melanoma development
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