Structural Maintenance of Chromosomes 5 (SMC5) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
SMC5 Antibody is a Rabbit Polyclonal antibody against SMC5.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Structural Maintenance of Chromosomes 5 (SMC5) Immunogen: Recombinant fusion protein corresponding to human SMC5 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/1000 - 1/3000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 128 kDa Observed MW: 132 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8IY18 |
| Gene ID | 23137 |
| NCBI Accession | NP_055925.2 |
| Background | Antibody anti-SMC5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Related Products
SMC5 antibody
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT(alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex(telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies(APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome(PubMed:26983541).
Ver Producto
Structural Maintenance of Chromosomes 5 (SMC5) Antibody
SMC5 Antibody is a Rabbit Polyclonal antibody against SMC5.
Ver Producto
Structural Maintenance of Chromosomes 5 (SMC5) Antibody
Structural Maintenance Of Chromosomes 5 Antibody is a Rabbit Polyclonal antibody against Structural Maintenance Of Chromosomes 5.
Ver Producto