TNF Receptor-Associated Factor 4 (TRAF4) Antibody
52€ (10 µg)
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Name
TNF Receptor-Associated Factor 4 (TRAF4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx015109
Tested Applications
ELISA, WB
Description
Rabbit polyclonal antibody against TRAF4 protein. Immunogen region is Internal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: TNF Receptor-Associated Factor 4 (TRAF4) Immunogen: The antiserum was produced against synthesized peptide derived from internal of human TRAF4. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BUZ4 |
| Alias | TRAF-4,TRAF4, CART1, MLN62, RNF83, TNF receptor associated factor 4,RING finger protein 83 |
| Background | Antibody anti-TRAF4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TRAF4 is a unique member of the TRAF family that regulates signaling pathways involved in cellular processes such as survival, migration, and cytoskeletal organization. Unlike other TRAF proteins, TRAF4 interacts with various receptors, including TNFR superfamily members, Toll-like receptors, and growth factor receptors, linking them to downstream signaling cascades like Akt, MAPK, and NF-κB. TRAF4 is highly expressed during embryonic development and in epithelial cells, where it plays a role in tissue morphogenesis, cell polarity, and immune responses. It also participates in reactive oxygen species (ROS) regulation and ciliary function. Dysregulation of TRAF4 has been associated with cancer progression, where it promotes epithelial-mesenchymal transition (EMT), cell migration, and invasion. Knockout studies reveal defects in neural tube closure, abnormal epithelial development, and impaired ciliary function, emphasizing its roles in developmental processes and cytoskeletal regulation.
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